Xiaoming Zeng

13281058102
Professor, Ph.D.
zengxiaoming@scu.edu.cn

Professor

College of Chemistry, Sichuan University

No. 24 South Section 1, Yihuan Road, Chengdu 610064, P. R. China.

Tol/Fax:   (+86)-13281058102

Email:       zengxiaoming@scu.edu.cn

Research FieldOrganometallic Chemistry, Synthetic Chemistry, Chromium Catalysis, Arene Hydrogenation

 

Education

Sep/2007–Sep/2009            Joint Ph.D. Student                                                   

                                             Department of Chemistry                                     

                                             University of California, Riverside (UCR), USA

                                             (Supervisor: Professor Guy Bertrand)

Sep/2004–Dec/2009             Ph.D. in Organic Chemistry                                   

                                              Department of Chemistry

                                              Sichuan University, Chengdu, China          

                                              (Supervisor: Prof. Meiming Luo)

Sep/1998–Jul/2002               B.S. in Applied Chemistry                                 

                                              Sichuan Normal University, Chengdu, China

 

Professional Experience

May/2017–Present               Professor   

                                             College of Chemistry  

                                             Sichuan University, China

Jan/2012–Apr/2017            Professor   

                                            Center for Organic Chemistry (COC)  

                                             Frontier Institute of Science and Technology

                                             Xi’an Jiaotong University (XJTU), China

Apr/2010–Dec/2011            JSPS Research Fellow                                                           

                                             Department of Chemistry                                 

                                             University of Tokyo, Japan                       

                                             (Supervisor: Professor Eiichi Nakamura)

Sep/2008–Sep/2009            Junior Researcher                                                        

                                             Department of Chemistry                               

                                             University of California, Riverside (UCR), USA

                                      

Honors and Awards

?  ACP Lectureship Award to Japan & Singapore (2019)

?  Reserve candidates for academic and technological leaders in Sichuan Province (2018)

?  1000 Young Talent Program of Sichuan Province (2017)

?  High Level Introduction of Talent Researcher in Sichuan University (2017)

?  The Youth Talent Support Program in Xi’an Jiaotong University (2016)

?  3-Year Membership Award to the American Chemical Society (2015)

?  JSPS Postdoctoral Fellowship for Foreign Researchers (Japan Society for the Promotion of Science, 2010–2012)

? Research Fellowship of China Scholarship Council (CSC) (2007–2009) 


Research Interests

(1)   The development of low-valent Cr-catalyzed reactions for molecule synthesis.

(2)   The exploration of the ligand behavior of cyclic mono(amino)carbenes (CMAC) and development of CMAC-Cr-catalyzed organic reactions.

 

Publications

1.    Xue Zhang, Liang Ling, Meiming Luo, and Xiaoming Zeng*

Accessing Equatorially Difluoromethylated and Trifluoromethylated cis-Cycloalkanes and Saturated Heterocycles by Preferential Hydrogen-Addition to the Substitution Sites for Dearomatization

Angew. Chem. Int. Ed. 2019, DOI: 10.1002/anie.201907457. [Link

2.    Zhi Rong, Meiming Luo,* and Xiaoming Zeng*

Modular Arene Difunctionalization by Sequential Cleavage of Unactivated C–O and C–H Bonds in One Pot with Chromium Catalysis

      Org. Lett. 2019, 21(17), 6869–6873. [Link] 

3.   Hong Meng, Sen Gao, Xiaoming Zeng,* and Xiaoming Zeng*

      Iron and Phenol CoCatalysis for Rapid Synthesis of Nitriles under Mild Conditions

Eur. J. Org. Chem. 2019, 4617?4623. [Link] 

4.      Bo Han, Pengchen Ma, Xuefeng Cong, Hui Chen,* and Xiaoming Zeng*

Chromium- and Cobalt-Catalyzed, Regiocontrolled Hydrogenation of Polycyclic Aromatic Hydrocarbons: A Combined Experimental and Theoretical Study?

      J. Am. Chem. Soc. DOI: 10.1021/jacs.9b03328. [Link] 

5.      Liang Ling,? Yuan He, ? Xue Zhang, Meiming Luo, and Xiaoming Zeng*

Hydrogenation of (Hetero)aryl Boronate Esters with a Cyclic (Alkyl)(amino)carbene-Rhodium Complex: Direct Access to cis-Substituted Borylated Cycloalkanes and Saturated Heterocycles?

      Angew. Chem. Int. Ed. 2019, 58, 6554 –6558. [Link] 

6.      Liang Ling,? Changpeng Chen, ? Meiming Luo,* and Xiaoming Zeng*

Chromium-Catalyzed Activation of Acyl C–O Bonds with Magnesium for Amidation of Esters with Nitroarenes?

      Org. Lett. 2019, 21, 1912–1916. [Link] 

7.      Jinghua Tang,? Xuejiao J. Gao, ? Huarong Tang,* and Xiaoming Zeng*

Dioxygen activation with stable N-heterocyclic carbenes?

      Chem. Commun. 2019, 55, 1584–1587. [Link] 

8.       Pei Liu,? Changpeng Chen,? Xuefeng Cong,? Jinghua Tang, and Xiaoming Zeng*

     Chromium-catalyzed para-selective formation of quaternary carbon centers by alkylation of benzamide derivatives?

Nat. Commun. 2018, 9, 4637. [Link] 

9.      Jinghua Tang, Pei Liu, and Xiaoming Zeng*

     N-Heterocyclic carbene–chromium-catalyzed alkylative cross-coupling of benzamide derivatives with aliphatic bromides

      Chem. Commun. 2018, 54, 9325–9328. [Link]

10.      Fei Fan, Jinghua Tang, Meiming Luo,* and Xiaoming Zeng*

     Chromium-Catalyzed Regioselective Kumada Arylative Cross-Coupling of C(aryl)–O Bonds with a Traceless Activation Strategy

      J. Org. Chem. 201883, 13549–13559. [Link]

11.      Changpeng Chen, Pei Liu, Meiming Luo, and Xiaoming Zeng*

     Kumada Arylation of Secondary Amides Enabled by Chromium Catalysis for Unsymmetric Ketone Synthesis under Mild Conditions

      ACS Catal. 20188, 5864–5868. [Link]

12.      Yuan He, Jinghua Tang, Meiming Luo,* and Xiaoming Zeng*

     Regioselective and Chemoselective Reduction of Naphthols Using Hydrosilane in Methanol: Synthesis of the 5,6,7,8-Tetrahydronaphthol Core

      Org. Lett. 201820, 4159–4163. [Link]

13.  Lei Jia, Qiang Tang, Meiming Luo,* and Xiaoming Zeng*

Direct ortho-Selective Amination of 2-Naphthol and Its Analogues with Hydrazines

J. Org. Chem. 201883, 5082–5091. [Link]

 

14.  Xuefeng Cong,§ Fei Fan,§ Pengchen Ma,§ Meiming Luo, Hui Chen,* and Xiaoming Zeng*

Low-Valent, High-Spin Chromium-Catalyzed Cleavage of Aromatic Carbon–Nitrogen Bonds at Room Temperature: A Combined Experimental and Theoretical Study

J. Am. Chem. Soc. 2017, 139, 15182?15190. [Link]

15.  Lei Jia, Qiang Tang, Meiming Luo,* and Xiaoming Zeng*

One-Step Synthesis of Unsymmetric 1,1’-Biaryl-2,2'-diamines by the Reaction of 2-Naphthols with Aryl Hydrazines

Chin. J. Org. Chem. 2018, 38, 443–450. [Link]?

16.  Jinghua Tang, Meiming Luo,* and Xiaoming Zeng*

Chromium-Catalyzed, Regioselective Cross-Coupling of C–O Bonds Using Organic Bromides as Reactants

Synlett, 2017, 28, 2577–2580. (Invited for cluster of “C–O bond activation”) [Link]

17.  Sen Gao, Liming Gao, Hong Meng, Meiming Luo,* and Xiaoming Zeng*

Iron-Catalyzed Synthesis of Benzoxazoles by Oxidative Coupling/Cyclization of Phenol Derivatives with Benzoyl Aldehyde Oximes

Chem. Commun., 2017, 53, 98869889. [Link]

18.  Changpeng Chen, and Xiaoming Zeng*

Ruthenium-Catalyzed Alkynylation of Benzoic Acids Mediated by a Weakly-Coordination Directing Auxiliary

Eur. J. Org. Chem. 2017, 4749–4752. [Link]

19.  Changpeng Chen, Pei Liu, Jinghua Tang, Gongda Deng, and Xiaoming Zeng*

Iridium-Catalyzed, Weakly Coordination-Assisted Ortho-Alkynylation of (Hetero)aromatic Carboxylic Acids without Cyclization

Org. Lett. 201719, 2474–2477. [Link]

20.  Pei Liu, Jinghua Tang, and Xiaoming Zeng*

Site-Selective Silylation of Aliphatic C–H Bonds Mediated by [1,5]-Hydrogen Transfer: Synthesis of α-Sila Benzamides

Org. Lett. 2016, 18, 5536–5539. [Link] 

21.  Bin Rao, Jinghua Tang, and Xiaoming Zeng*

Synthesis of 2-Benzylphenyl Ketones by Aryne Insertion into Unactivated C–C Bonds

 Org. Lett. 2016, 18, 1678–1681. [Link] 

22.  Xuefeng Cong, Shengxian Zhai, and Xiaoming Zeng*

Low-Valent Cobalt-Catalyzed C–H Allylation

Org. Chem. Front. 2016, 3, 673–677. (Invited as “2015 Emerging Investigator by OCF”) [Link] 

23.  Yuexuan Li, Gongda Deng, and Xiaoming Zeng*

Chromium-Catalyzed Regioselective Hydropyridination of Styrenes

Organometallics 201635, 747–750. [Link]

24.  Bin Rao, Jinghua Tang, Yu Wei, and Xiaoming Zeng*

Ring Expansion via Cleavage of Benzylic C–C Bonds Enabling Direct Synthesis of Medium Ring-fused Benzocarbocycles

Chem.–Asian J. 201611, 991–995. [Link]

25.   Xuefeng Cong, Huarong Tang, and Xiaoming Zeng*

Regio- and Chemoselective Kumada–Tamao–Corriu Reaction of Aryl Alkyl Ethers Catalyzed by Chromium Under Mild Conditions

J. Am. Chem. Soc. 2015137, 14367–14372. [Link]

(Highlights by Synfacts, 2016, 12, 0192; ChemInform, 2016, 47, 21-126)

26.  Yu Wei, and Xiaoming Zeng*

Catalytic Strategies toward Selective Hydrogenation of Aromatic Ketones and Phenols: Facile Synthesis of Cyclohexyl Ketones

Synlett. 2016, 27, 650–655. (Invited Synpacts article)

27.  Bin Rao, Huarong Tang, Xiaoming Zeng*, Liu Liu, Mohand Melaimi and Guy Bertrand* 

Cyclic (Amino)(aryl)carbenes (CAArCs) as Strong σ-Donating and π-Accepting Ligands for Transition Metals

Angew. Chem. Int. Ed. 2015, 54, 14915–14919. [Link]

28.  Yu Wei, Bin Rao, Xuefeng Cong, and Xiaoming Zeng*

Highly Selective Hydrogenation of Aromatic Ketones and Phenols Enabled by Cyclic (Amino)(alkyl)carbene Rhodium Complexes

J. Am. Chem. Soc. 2015,137, 9250–9253. [Link]   

(Highlights by Chin. J. Org. Chem. 2015, 35, 2019; ChemInform, 2016, 47, 03-038)

29.  Xiaoming Zeng* and Xuefeng Cong

Chromium-Catalyzed Transformations Using Grignard Reagents: New Opportunities for Cross-Coupling Reactions

Org. Chem. Front. 2015, 2, 69–72. [Link] 

30.  Xuefeng Cong, Yuexuan Li, Yu Wei, and Xiaoming Zeng*

Nickel-Catalyzed C–H Coupling with Allyl Phosphates: A Site-Selective Synthetic Route to Linear Allylarenes

Org. Lett. 2014, 16, 3926–3929. [Link] 

(Highlight by ChemInform, 2015, 46, 05-054)

31.  Xuefeng Cong and Xiaoming Zeng*

Iron-Catalyzed, Chelation-Induced Remote C–H Allylation of Quinolines via 8-Amido Assistance

Org. Lett. 2014, 16, 3716–3719. [Link]

(Highlight by ChemInform, 2015, 46, 02-047)

32.   Yu Wei,§ Huarong Tang,§ Xuefeng Cong, Bin Rao, Chao Wu* and Xiaoming Zeng*

Pd(II)-Catalyzed Intermolecular Arylation of Unactivated C(sp3)–H Bonds with Aryl Bromides Enabled by 8-Aminoquinoline Auxiliary

Org. Lett. 2014, 16, 2248–2251. [Link] 

(Highlight by ChemInform, 2014, 45, 41-085)

33.  Bin Rao and Xiaoming Zeng*

Aminocyanation by the Addition of N–CN Bonds to Arynes: Chemoselective Synthesis of 1,2-Bifunctional Aminobenzonitriles

Org. Lett., 2014, 16, 314–317. [Link]  

(Highlights by ChemInform, 2014, 45, 23-095; Org. Chem. Highlights 2014, October 13)

34.  Xuefeng Cong,§ Huarong Tang,§ Chao Wu*, and Xiaoming Zeng*

Role of Mono-N-Protected Amino Acid Ligands in Pd(II)-Catalyzed Dehydrogenative Heck Reactions of Electron-Deficient (Hetero)Arenes: Experimental and Computational Studies

Organometallics, 2013, 32, 6565–6575. [Link]  

35.  Yu Wei, Jinghua Tang, Xuefeng Cong, and Xiaoming Zeng*

Practical Metal-Free Synthesis of Chalcone Derivatives via a Tandem Cross-Dehydrogenative-Coupling/Elimination Reaction

Green Chem. 2013, 15, 3165–3169. [Link]

(Highlight by ChemInform, 2014, 45, 12-079)

36.   Xiaoming Zeng*

Recent Advances in Catalytic Sequential Reactions Involving Hydroelement Addition to Carbon–Carbon Multiple Bonds

Chem. Rev. 2013, 113, 6864–6900. [Link]  (ESI highly cited paper)

37.  Pei Guo, Xiaoming Zeng, Si Chen, and Meiming Luo*

Au(I)–N-heterocyclic carbene complex-catalyzed synthesis of 1-substituted benzo[b][1,4]diazepines from N-substituted o-phenylenediamines and terminal alkynes

J. Organomet. Chem. 2013, 751, 438–442. [Link]  

38.  Xiaoming Zeng, Laurean Ilies, and Eiichi Nakamura*

Iron-Catalyzed Regio- and Stereoselective Chloro-sulfonylation of Terminal Alkynes with Aromatic Sulfonyl Chlorides

Org. Lett. 2012, 14, 954–956. [Link]

 (Highlight by ChemInform, 2012, 43, 23-088)

39.  Xiaoming Zeng, Laurean Ilies, and Eiichi Nakamura*

Synthesis of Functionalized 1H-Indenes via Copper-Catalyzed Arylative Cyclization of Arylalkynes with Aromatic Sulfonyl Chlorides

J. Am. Chem. Soc. 2011, 133, 17638–17640. [Link] 

40.  Laurean Ilies, Quan Chen, Xiaoming Zeng, and Eiichi Nakamura*

Cobalt-Catalyzed Chemoselective Insertion of Alkene into the ortho-C–H Bond of Benzamide

J. Am. Chem. Soc. 2011, 133, 5221–5223. [Link] 

41.  Xiaoming Zeng, Rei Kinjo, Bruno Donnadieu, and Guy Bertrand*

Serendipitous Discovery of the Catalytic Hydroammoniumation and  Methylamination of Alkynes

Angew. Chem., Int. Ed. 2010, 49, 942–945. [Link]  

42.  Xiaoming Zeng, Guido D. Frey, Rei Kinjo, Bruno Donnadieu, and Guy Bertrand*

Synthesis of a Simplified Version of Stable Bulky and Rigid Cyclic (Alkyl)(amino)carbenes, and Catalytic Activity of the Ensuing Gold(I) Complex in the Three-Component Preparation of 1,2-Dihydroquinoline Derivatives

J. Am. Chem. Soc. 2009, 131, 8690–8696. [Link] 

43.  Xiaoming Zeng, Guido D. Frey, Shazia Kousar, and Guy Bertrand*

A Cationic Gold(I) Complex as a General Catalyst for the Intermolecular Hydroamination of Alkynes: Application to the One-Pot Synthesis of Allenes from Two Alkynes and a Sacrificial Amine

Chem.–Eur. J. 2009, 15, 3056–3060. [Link] 

44.  Xiaoming Zeng, Michele Soleilhavoup, and Guy Bertrand*

Gold-Catalyzed Intermolecular Markovnikov Hydroamination of Allenes with Secondary Amines

Org. Lett. 2009, 11, 3166–3169. [Link] 

45.  Xiaoming Zeng, Tongxin Zhang, Yuancheng Qin, Zhijun Wei, and Meiming Luo*

Synthesis of a Carbene Transfer Organometallic Polymer and Application to Forming a Recyclable Heterogeneous Catalyst for the Suzuki Reactions of Arylchlorides

Dalton Trans. 2009, 8341–8348. [Link]   

46.  Sujuan Zhang, Xiaoming Zeng, Zhijun Wei, Dongbing Zhao, Tairan Kang, Weifeng Zhang, Mei Yan, and Meiming Luo*

Desulfitative Suzuki Cross-Couplings of Arylsulfonyl Chlorides and Boronic Acids Catalyzed by a Recyclable Polymer-Supported N-Heterocyclic Carbene-Palladium Complex Catalyst

Synlett 2006, 1891–1894.  

47.  Chun Yan, Xiaoming Zeng, Weifeng Zhang, and Meiming Luo*

Polymer-Supported N-Heterocyclic Carbene–Rhodium Complex Catalyst for the Addition of Arylboronic Acids to Aldehydes

J. Organomet. Chem. 2006, 691, 3391–3396. [Link]